Synchrotron light has been used in the last decades to study formulations manufactured by the pharmaceutical, cosmetic and food industry. The use of synchrotron light has allowed characterizing liquid and solid formulations, i.e. fingerprinting compounds and quantifying traces of polymorphs in a solid tablet formulation, and characterizing variants in biopharmaceuticals. Moreover, the presence of last generation synchrotron facilities as MAX IV (Lund, Sweden) will definitely bring the research in these areas beyond the limitations faced nowadays. Despite of synchrotron light being a very powerful source to help understanding formulations, it is still not broadly used due to limitations in several steps of the measurement process, i.e. sample preparation, measurement planning and data interpretation. To understand what information can be obtained when using synchrotron light for the characterization of formulations, to know how to proceed for performing the most optimal and fruitful experiment in a synchrotron and to interpret the results is key to make the best use of these methods, which will undoubtedly lift formulation research, production and development activities up to much higher standards.
This is the first in a series of courses with a goal to educate and enlarge the user base from industry and academia to utilize the potential of Big Science facilities like MAX IV and ESS and the interdisciplinary research at Lund University.
Small-angle X-ray scattering (SAXS) and X-ray powder diffraction (XRPD) are key tools to support research, development, manufacturing and life cycle management activities for pharmaceuticals, food and aroma compounds, cosmetics, pigments, catalysts, cement. Typical applications in formulation include:
- Structural changes of formulations in the presence of additives
- Self-assembly of surfactants and polymers
- Material Characterization for QbD – excipients and ingredients
- Gel network microstructure and stability
- Fingerprinting of compounds
- Quantification of impurities
The aim of the course is twofold: to provide participants with the understanding of the key information obtained by using synchrotron light to better understand a solid or liquid formulation. In addition, the course aims at describing the ecosystem that surrounds MAX IV Laboratory, including the actors that are present to help industry to make the best use of the such state-of-the-art large-scale infrastructure, i.e. planning the experiments, carrying out the measurements and performing the data interpretation. At completion of the course, the participant will have gained an understanding on the capabilities of synchrotrons as MAX IV to solve current challenges in the characterization of formulations.
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This is a course combining science and applications of the use of synchrotron light within formulation science. Thus, it is aimed at R&D Managers, industrial specialists and project leaders at companies, as well as university researchers, who want to learn how they can make use of and benefit from synchrotron light within formulation science.
Tid & plats
The course will take place September 27-28, 2017 at Lund University.
Fabia Gozzo has more than 10 years of practical experience with synchrotron light from the Paul Scherrer Institute, where she has developed a state-of-the-art powder diffractometer. She is also head of the spin-off company Excelsus Structural Solutions in Switzerland. She is recognized as a synchrotron- and powder diffraction expert, and has built a substantial industrial and academic user community, including some large pharmaceutical companies.
Peter Schurtenberger is a professor in Physical Chemistry at Lund University. His research interests focus on soft matter, nanotechnology, biophysics, materials sciences, on the characterization of soft matter with light, X-ray and neutron scattering, and on the development of new instruments for this task. In 2006 he founded the Fribourg Center for Nanomaterials, and became the first director of the newly founded Adolphe Merkle Institute for Pure and Applied Nanoscience in 2008. He moved to Lund in 2010. He has been elected as a member of the Royal Swedish Academy of Sciences, the Royal Swedish Academy of Engineering Sciences, is a Fellow of the Royal Society of Chemistry, and honorary member of the European Colloid and Interface Society.
Bente Vestergaard is the group leader of the BioSAXS group, at the Drug Design and Pharmacology, University of Copenhagen, which has focused on structural biology throughout her career. Since 2004 she has specialized in small angle X-ray scattering on proteins in solution and have established the first Scandinavian bioSAXS group at the University of Copenhagen.
Other lecturers include Stefan Ulvenlund (CSO at CR Competence AB and professor in Formulation Technology at Lund University), Marc Obiols-Rabasa (scientist at CR Competence AB with 10 years of experience in the characterization of soft nanomaterials using scattering methods such as light, X-rays and neutrons), Tomás Plivelic (Beamline manager at MAX IV) and Marjolein Thunissen (Head User Office at MAX IV).
Lunds universitet är ett av Europas ledande forskningsuniversitet, rankat som nummer ett i Sverige och bland de hundra bästa universiteten i världen. Det betyder att våra uppdragsutbildningar förmedlar kunskap som ligger i absolut framkant. Vi har lång erfarenhet av att...
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